The only exception are MASTER FILES which have seniority over all other mods in the structure. Mods closer to the bottom have a priority on the load list and thus their changes will override any others above them. Simply install the mods on the list from top to bottom in the exact order for compatibility.

The mod list is presented in it's optimal load order.

Loading an existing save after making such changes can and will have undesirable effects such as poor performance, game crashes and potential save corruption. Due that mods alter a significant portion of the game and can change the world state.

ALWAYS USE A CLEAN SAVE / START A NEW GAME.

Important information for XBOX ONE mod users New locations and villages with new NPCs that integrate into the existing world seamlessly. Gameplay and combat overhauls, quest additions, graphics, audio, and ui changes. This is a much more comprehensive list covering almost every aspect of the game. OmegaDL50's Optimal Xbox Mod Order (As of March 2019)

Never replace, just build on top of and improve further. I carefully select mods that refine and further improve what is already and expand on it. Keep in mind the mods I typically use are more of an accompaniment to the original game instead of replace the intent of the original creators. Of course if you plan to play Skyrim only once and don't plan for repeated playthroughs, then a fully modded experience might give you most refined experience out of the game. So it will reduce a lot of potential problems even for the original experience without any graphics or gameplay enhancements other mods do. There is hundreds potentially thousands of issues that the USP fixes that Bethesda themselves never got around to actually fixes themselves.

Even if you plan to play Skyrim, even a vanilla playthrough should not be without using the Unofficial Skyrim Patch. You should at least try the original unaltered game first, and then play with mods to appreciate how improved the changes actually are. I think as a fair point if you never played Skyrim before on any platform.

There is huge swath of improvements visuals, to the crafting, level environments, new quests, new landmasses to explore, improved gameplay mechanics such as combat overhauls, survival elements, and so forth. I cannot stand playing Skyrim without mods anymore.

Beasts of tamriel sse